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《医学前沿(英文)》 2022年 第16卷 第6期 页码 873-882 doi: 10.1007/s11684-022-0925-2
关键词: Salmonella VNP20009 tumstatin B16F10 melanoma apoptosis angiogenesis
Zfyve16 regulates the proliferation of B-lymphoid cells
Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren
《医学前沿(英文)》 2018年 第12卷 第5期 页码 559-565 doi: 10.1007/s11684-017-0562-3
Zfyve16 (a.k.a. endofin or endosome-associated FYVE-domain protein), a member of the FYVE-domain protein family, is involved in endosomal trafficking and in TGF-β, BMP, and EGFR signaling. The FYVE protein SARA regulates the TGF-β signaling pathway by recruiting Smad2/3 and accelerating their phosphorylation, thereby altering their susceptibility to TGF-β-mediated T cell suppression. Zfyve16 binds to Smad4 and their binding affects the formation of Smad2/3-Smad4 complex in TGF-β signaling. However, the in vivo function of Zfyve16 remains unknown. In this study, we generated a Zfyve16 knockout mouse strain (Zfyve16KO) and examined its hematopoietic phenotypes and hematopoietic reconstruction ability. The proportion of T cells in the peripheral blood of Zfyve16KO mice increases compared with that in wild-type mice. This finding is consistent with the role of Zfyve16 in facilitating TGF-β signaling. Unpredictably, B cell proliferation is inhibited in Zfyve16KO mice. The proliferation potential of Zfyve16KO B-lymphoid cells also significantly decreases in vitro. These results suggest that Zfyve16 inhibits the proliferation of T cells, possibly through the TGF-β signaling, but upregulates the proliferation of B-lymphoid cells.
孙玉坤,朱志莹,黄振跃,唐平
《中国工程科学》 2012年 第14卷 第7期 页码 93-97
设计了一款以dsPIC30F4012为主控制器、PIC16F877A为从处理器的新型主从式选择性漏电保护系统。
FAMODIMU, Mark STANFORD, Chike F. ODUOZA, Lijuan ZHANG
《机械工程前沿(英文)》 2018年 第13卷 第4期 页码 520-527 doi: 10.1007/s11465-018-0521-y
Laser melting of aluminium alloy—AlSi10Mg has increasingly been used to create specialised products in various industrial applications, however, research on utilising laser melting of aluminium matrix composites in replacing specialised parts have been slow on the uptake. This has been attributed to the complexity of the laser melting process, metal/ceramic feedstock for the process and the reaction of the feedstock material to the laser. Thus, an understanding of the process, material microstructure and mechanical properties is important for its adoption as a manufacturing route of aluminium metal matrix composites. The effects of several parameters of the laser melting process on the mechanical blended composite were thus investigated in this research. This included single track formations of the matrix alloy and the composite alloyed with 5% and 10% respectively for their reaction to laser melting and the fabrication of density blocks to investigate the relative density and porosity over different scan speeds. The results from these experiments were utilised in determining a process window in fabricating near-fully dense parts.
关键词: selective laser melting additive manufacturing mechanical alloying powder metallurgy aluminium metal matrix composite
Impact analysis of compressor rotor blades of an aircraft engine
Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU
《结构与土木工程前沿(英文)》 2019年 第13卷 第3期 页码 505-514 doi: 10.1007/s11709-018-0493-3
关键词: axial flow compressor rotor and stator blades aircraft engine stress and impact analysis aluminum alloys
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 72-80 doi: 10.15302/J-FASE-2016089
F. D’ Intino,B. de Caprariis,M.L. Santarelli,N. Verdone,A. Chianese
《化学科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 156-160 doi: 10.1007/s11705-014-1427-9
Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
《医学前沿(英文)》 2008年 第2卷 第2期 页码 195-199 doi: 10.1007/s11684-008-0037-7
关键词: chemotactic activity receptor uPA inhibitor F10 chemoattractant
组织工程和给药技术中的三维光制造 Review
Rúben F. Pereira, Paulo J. Bártolo
《工程(英文)》 2015年 第1卷 第1期 页码 90-112 doi: 10.15302/J-ENG-2015015
组织工程中最有前景的方法就是将生物材料、细胞和生物活性分子结合加入人工的模拟环境,用以准确地模拟人体组织修复环境,并刺激组织修复和再生。这个环境必须在细胞或亚细胞尺度上模拟出尽可能接近原生细胞外基质的主要特性,只有这样此方法才会在临床应用上有效。光制造技术通过多层工艺,如对光敏预聚物的选区光交联反应,构建包含精确结构和多相材料组合的环境。细胞和治疗分子可以包含在初始水凝胶前体的溶液中,并加工成三维(3D)结构。近来,光制造也已被开发用来动态调节水凝胶的实时特性,加强控制细胞寿命和生物活性物质的传递。本文聚焦于利用3D光制造技术为组织再生和给药技术生产先进结构的相关研究,同时介绍了目前最先进的光制造技术,重点放在控制细胞生物活性因子分布形式的工作原理和生物制造方法上。因光制造技术具有工艺快速、时空控制、高分辨率和高精度等特性,故其在复杂的3D结构设计中扮演着重要角色。这种技术同样能够为组织再生构建适当的环境,并可调节治疗方法的实施状况。
Bright, Emma B. Veale, Adam F. Henwood, D. Clive Williams, Thorfinnur Gunnlaugsson
《化学科学与工程前沿(英文)》 2020年 第14卷 第1期 页码 61-75 doi: 10.1007/s11705-019-1862-8
关键词: sensors pH photoinduced electron transfer cellular imaging confocal microscopy
DONG Yongli, YUAN Fulong, ZHU Yujun, ZHAO Lina, CAI Zhicheng
《化学科学与工程前沿(英文)》 2008年 第2卷 第2期 页码 150-154 doi: 10.1007/s11705-008-0036-x
关键词: different CuO/SBA-16 temperature physisorption introduction
医疗机构中用于控制空气传播传染病的个体患者通风隔离罩 Review
Patel, F. McGain, T. Bhatelia, S. Wang, B. Sun, J. Monty, V. Pareek
《工程(英文)》 2022年 第15卷 第8期 页码 126-132 doi: 10.1016/j.eng.2020.12.024
作为一种局部排气通风(LEV)系统,个体患者通风(VIP)隔离罩用于将患者的空气排放物与医护人员(HCW)呼吸的空气进行分离,为减少医院获得性感染(HAI)提供了一种新的途径。最近的研究结果表明,对于典型的患者排放的气溶胶,VIP 隔离罩提供的保护与N95 口罩相当。与口罩不同的是,隔离罩的性能可以被很容易地监控,HCW可以通过警报收到故障提醒。适当使用这些相对简单的设备既可以减少感染控制对个人防护设备(PPE)的依赖,又可以为医院和诊所提供低成本、高能效的防护形式。尽管新冠病毒肺炎(COVID-19)加速了VIP 隔离罩的开发和部署,但这些设备目前仍是一项不成熟的技术。本文描述了VIP隔离罩的现状,并确定了需要进一步开发的方面,包括设备设计和相关使用规则。VIP隔离罩的概念可扩展为为个体患者提供清洁的条件和对其他环境因素如温度和湿度进行个性化控制。
F. PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 203-209 doi: 10.1007/s11705-012-1277-2
关键词: recombinant destabilase-lysozyme (rec.Dest-Lys) antimicrobial activity antifungal activity medicinal leech heated-up derivative of rec.Dest-Lys (T-rec.Dest-Lys)
PM10 emissions from industrial coal-fired chain-grate boilers
Xinghua Li, Junzan Han, Lei Duan
《环境科学与工程前沿(英文)》 2017年 第11卷 第6期 doi: 10.1007/s11783-017-0966-y
关键词: coal-fired chain-grate boiler PM10 size distribution particulate emission control devices size-dependent collection efficiency
标题 作者 时间 类型 操作
Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis
期刊论文
Zfyve16 regulates the proliferation of B-lymphoid cells
Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren
期刊论文
Effect of process parameters on the density and porosity of laser melted AlSi10Mg/SiC metal matrix composite
FAMODIMU, Mark STANFORD, Chike F. ODUOZA, Lijuan ZHANG
期刊论文
Impact analysis of compressor rotor blades of an aircraft engine
Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU
期刊论文
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
期刊论文
Best operating conditions to produce hydroxyapatite nanoparticles by means of a spinning disc reactor
F. D’ Intino,B. de Caprariis,M.L. Santarelli,N. Verdone,A. Chianese
期刊论文
Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
期刊论文
4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomal cellular imaging agents: The effect of substituent patterns on PET directional quenching
Bright, Emma B. Veale, Adam F. Henwood, D. Clive Williams, Thorfinnur Gunnlaugsson
期刊论文
Characterization and catalytic properties of mesoporous CuO/SBA-16 prepared by different impregnation
DONG Yongli, YUAN Fulong, ZHU Yujun, ZHAO Lina, CAI Zhicheng
期刊论文
Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up derivative
F. PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA
期刊论文